“持久影响”
用英语怎么说？

In the year 2000, researchers at Yale University published a groundbreaking study detailing how ketamine, a substance traditionally used as an anesthetic during surgery, could alleviate depressive symptoms within a single dose. Curiously, this therapeutic benefit persisted long after the acute psychoactive effects subsided. Around the same time, scientists at Johns Hopkins University began investigating psilocybin, the active compound in hallucinogenic mushrooms. Despite its classification as a highly restricted substance, participants reported that their experiences were deeply meaningful. Intrigued by these long-lasting effects, chemical neuroscientist David Olson embarked on a quest to understand the underlying mechanisms. These pioneering studies sparked a major paradigm shift, prompting researchers to wonder whether psychedelics could safely revolutionize psychiatric treatment and how molecular structures influence human consciousness and mood regulation.

在2000年，耶鲁大学的研究人员发表了一项突破性的研究，详细阐述了氯胺酮（一种传统上在手术中用作麻醉剂的物质）如何在单次剂量内缓解抑郁症状。奇特的是，这种治疗益处在急性精神活性作用消退后仍持续了很久。大约在同一时期，约翰斯·霍普金斯大学的科学家开始研究幻觉菇中的活性成分裸盖菇素。尽管它被列为高度管制的物质，但参与者报告称他们的经历深具意义。受这些持久影响的启发，化学神经科学家戴维·奥尔森开始探寻其背后的潜在机制。这些开创性的研究引发了重大的范式转变，促使研究人员思考幻觉剂是否能安全地彻底改变精神病治疗，以及分子结构如何影响人类的意识和情绪调节。